Emmanuel Israel Edache

In-silico Discovery and Simulated Selection of Multi-target Anti-HIV-1 Inhibitors

Emmanuel Israel Edache, Hambali Umar Hambali, David Ebuka Arthur, Adedirin Oluwaseye & Onoyima Christian Chinweuba · International Research Journal of Pure and Applied Chemistry · 2016

The multi-target quantitative structure-activity relationship (mt-QSAR) study of human immunodeficiency virus (HIV-1) inhibitors was addressed by applying a modest, hitherto active linear regression model based on the Genetic function approximation. QSAR studies were performed on...

Open access Research Article 10.9734/IRJPAC/2016/22863

QSAR Study of Series of HEPT (1-[(2-hydroxyethoxy) methyl]-6-(phenylthio)thyio)thymine) Derivatives Using Genetic Function Approximation as Anti-HIV-1 Agents

Emmanuel Israel Edache, Adamu Uzairu & Stephen Eyije Abechi · Current Journal of Applied Science and Technology · 2015

Aims/Objectives: Studies were performed to correlate the biological activity of the HEPT (1-[(2-hydroxyethoxy) methyl]-6-(phenylthio)thyio)thymine) 107 sets of compound with the independent descriptor to know the structural requirement of the drug receptor binding interaction. Me...

Open access Research Article 10.9734/BJAST/2016/21791

Development and Estimation of an in Silico Model for Anti-HIV-1 Integrase Inhibitor Using Genetic Function Approximation

Emmanuel Israel Edache, Adamu Uzairu & Stephen Eyije Abechi · Journal of Advances in Medical and Pharmaceutical Sciences · 2015

Aim: Integrase inhibitors are an essential enzyme required for replication of the acquired immunodeficiency syndrome virus. It is a potent target for anti- HIV therapy. A QSAR study is performed on the series indole -diketo, diketo acid and carboxamide derivatives in order to ana...

Open access Research Article 10.9734/JAMPS/2016/22227