Debaleena Samanta

Caspase-centred and Mitochondrial Apoptosis Signalling in Cancer: Pro-survival Rewiring, Therapeutic Vulnerabilities and Translational Constraints

Debaleena Samanta & Malavika Bhattacharya · Journal of Scientific Research and Reports · 2026

Apoptosis is a regulated cell-death programme in which upstream stress sensing is converted into mitochondrial outer membrane permeabilisation, caspase activation and ordered cellular dismantling. Cancer cells rarely abolish this machinery completely. Instead, they reconfigure it...