D. J. Shruthi

Natural Antisense Transcripts in Human Gene Regulation and Disease: A Critical Appraisal of Mechanisms and Therapeutic Prospects

M. D. Priya, K. Latha, D. J. Shruthi, S. Rajesha & H. B. Kiran Kumar · Journal of Advances in Biology & Biotechnology · 2026

Natural antisense transcripts (NATs) are RNA molecules transcribed from the DNA strand opposite a protein-coding or non-coding gene, and they constitute one of the most pervasive yet mechanistically heterogeneous classes of the mammalian non-coding transcriptome. Since large-scal...

Open access Research Article 10.9734/jabb/2026/v29i84176

PolyG (Polyglycine) Repeat and Human Diseases: An Update on the Biology, Diseases Mechanisms and Current Therapeutic Interventions

B. R. Mahalakshmi, J. N. Sharada Devi, D. J. Shruthi, B. K. Manjunath & H. B. Kiran Kumar · Journal of Applied Life Sciences International · 2026

Nucleotide repeats known as short tandem repeats (STRs) can be found in both coding and non-coding areas of the human genome such a polyglutamine (polyQ), polyglycine (polyG) and polyalanine (PolyA). PolyG repeat expansions, are caused by GGC repeat expansions leading to numerous...

Open access Research Article 10.9734/jalsi/2026/v29i2773