Effect of Vernonia Amygdalina Leaf on Cytochrome P450 2D6- and 3A4-Mediated Metabolism of Dextromethorphan in Healthy Nigerian Subjects
Mariam Olaide Oladepo, Adebanjo Jonathan Adegbola, Julius Olugbenga Soyinka & Cyprian Ogbona Onyeji · Journal of Advances in Medical and Pharmaceutical Sciences · 2021
Back-ground and Objectives: The study’s focus is to investigate the effects of Vernonia amygdalina on the metabolic activities of Cytochrome P450 3A4 and 2D6 in vivo. The assessment was based on CYP2D6-mediated O-demethylation and CYP3A4-mediated N-demethylation of dextromethorph...
Open access
Research Article
10.9734/jamps/2021/v23i230220