Cyprian O. Onyeji

Appraisal of Bioenhancers in Improving Oral Bioavailability: Applications to Herbal Medicinal Products

Francis A. Oladimeji, Adebanjo J. Adegbola & Cyprian O. Onyeji · Journal of Pharmaceutical Research International · 2018

The oral route of administration is associated with some challenges such as poor aqueous solubility and low intestinal permeability of many active pharmaceutical ingredients resulting in decreased drug absorption and subsequent poor bioavailability. In recent years, research on b...

Open access Research Article 10.9734/JPRI/2018/45330

Chemotherapeutic Interaction of Vernonia amygdalina (Delile) Leaf Extract with Artesunate and Amodiaquine in Murine Malaria Model

Esthinsheen Osirim, Oluwole I. Adeyemi, Sharon I. Igbinoba & Cyprian O. Onyeji · Journal of Pharmaceutical Research International · 2020

Aim of the Study: Conventional antimalarial drugs are used concurrently with herbal remedies in malarial endemic developing countries. Vernonia amygdalina is one of such popular herbs used in the treatment of malaria. This study aimed at investigating the antimalarial chemotherap...

Open access Research Article 10.9734/jpri/2020/v32i330410

Preparation and Physicochemical Evaluation of Lumefantrine-2-Hydroxypropyl-β-cyclodextrin Binary Systems

Adebanjo J. Adegbola, Ezekiel Omotoso, Olujide O. Olubiyi, Julius O. Soyinkaa, Oluseye O. Bolaji & Cyprian O. Onyeji · Journal of Pharmaceutical Research International · 2020

Lumefantrine contributes significant roles in artemisinin-based combination therapy for malaria treatment but associated with a limitation of poor aqueous solubility and low permeability. This study investigated lumefantrine-2-hydroxypropyl-β-cyclodextrin complex to improve its s...

Open access Research Article 10.9734/jpri/2020/v32i1330589