Catherine Rono

Role of HLA Class I Molecule in Cancer: Implications for Cancer Immunotherapy

Josiah Stephen, Ikechukwu Kanu, Nwamaka Nneka Onyedum, Edibokun Theresa Orobator, Catherine Rono, Ngwoke, Chinaza Faith, Victor Omeiza David, Wonderful Oluwatoyin Anosike & Lawrence John AJutor · Journal of Cancer and Tumor International · 2025

HLA class I molecules are essential for presenting tumour antigens to cytotoxic T-cells, but their dysregulation in cancer enables immune evasion and limiting the efficacy of immunotherapies for cancer. The objective of this review is to explore the function of HLA class I change...

Open access Research Article 10.9734/jcti/2025/v15i3299

The Role of the Tumor Microenvironment in Cancer Progression and Metastasis

Oseghale, Ikalo David, Ikokwu, Godwin Mmaduabuchi, Ugoagwu, Kingsley Ugonna, Elizabeth Anuoluwa Akintayo, Matthew Gyang, Okiki Nosiru Quadri, Catherine Rono, Osedebamen Hilary Ralph-Okhiria & Odunvbun Praise · Journal of Cancer and Tumor International · 2025

The tumor microenvironment (TME) is the complex ecosystem surrounding a tumor. It is a complex and continuously evolving entity. The TME comprises a variety of complex components, such as cancer cells, immune cells, stromal cells, and extracellular matrix, that precisely regulate...

Open access Research Article 10.9734/jcti/2025/v15i2297