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C. A. Obafemi

Publications (7)

Synthesis of Sulfanoquinoxaline-2,3-Dione Hydrazones Derivatives as a Selective Inhibitor for Acetylcholinesterase and Butyryl Cholinesterase

F. O. Taiwo, C. A. Obafemi, E. M. Obuotor & I. J. Olawuni · Journal of Applied Life Sciences International · 2021

Some Sulfanoquinoxaline-2,3-diones hydrazone derivatives (1-8) were synthesized from the reactions of 2,3-dioxoquinoxaline-6-sulfonohydrazine with seven substituted benzaldehydes and acetophenone. All the synthesized compounds were biologically evaluated against cholinesterase’s...

Open access Research Article 10.9734/jalsi/2021/v24i830252

Synthesis of Some Phenylisoindoline-1,3-Diones and their Acetylcholinesterase and Butyryl Cholinesterase Inhibitory Activities

F. O. Taiwo, C. A. Obafemi, E. M. Obuotor & I. J. Olawuni · Journal of Pharmaceutical Research International · 2021

Aims: To synthesize some phthalimides derivatives and evaluate the compounds for their possible biological properties. Methods: The substituted phenylisoindoline-1,3-dione were synthesized from the reactions of N-phenyl phthalimide with different substituted aromatic aldehyde. Th...

Open access Research Article 10.9734/jpri/2021/v33i51B33539

Design, Synthesis and Biological Activities of Some phthalimides Derivatives

F. O. Taiwo, C. A. Obafemi, E. M. Obuotor & I. J. Olawuni · Current Journal of Applied Science and Technology · 2021

Aims: To synthesize some phthalimides derivatives and evaluate the compounds for their possible biological properties. Methods: The substituted phenylisoindoline-1,3-dione were synthesized from the reactions of N-phenyl phthalimide with different substituted aromatic aldehyde. Th...

Open access Research Article 10.9734/cjast/2021/v40i3331563

Design, Synthesis and Antibacterial Activity of some 3,6-Dimethlyquinoxaline-2-Hydrazone Derivatives

F. O. Taiwo, C. A. Obafemi, D. A. Akinpelu & T. O. Iyiola · Journal of Applied Life Sciences International · 2021

Aims: This aims of this study was to continue the effort to synthesis new quinoxaline-based heterocycles and study its antibacterial properties. Objective: This study was designed to reacts 3,6-dimethylquinoxaline-2-hydrazine with some substituted aromatic ketones and study their...

Open access Research Article 10.9734/jalsi/2021/v24i630244

Synthesis of (Z)-2-((2-(Benzylideneamino)ethyl)Amino)-3-Methylquinoxaline-6-Sulfonyl Azide Derivatives and Their Acetylcholinesterase and Butyryl Cholinesterase Inhibitory Activities

Taiwo, F. O, O. B. Omoyeni, I. J. Olawuni, E. G. Fakola & C. A. Obafemi · Journal of Applied Life Sciences International · 2026

Aims: This study synthesized  a series of (Z)-2-((2-(benzylideneamino)ethyl)amino)-3-methylquinoxaline-6-sulfonyl azide derivatives and evaluated their inhibitory activities against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Methods: The derivatives were prepar...

Open access Research Article 10.9734/jalsi/2026/v29i5800

Design, Synthesis and Biological Evaluation of (Z)-N,N-dibenzyl-3-oxo-2-((2-((1 phenylethylidene) amino)ethyl)amino)-3,4-dihydroquinoxaline-6-sulfonamide Derivatives

F. O. Taiwo, O. B. Omoyeni, I. J. Olawuni, E. G. Fakola & C. A. Obafemi · Current Journal of Applied Science and Technology · 2026

Aims: The aim is to synthesize a range of chemical derivatives and thoroughly evaluate their potential biological activities. This process will involve designing and executing synthetic pathways to obtain the desired compounds, followed by in-depth biological assays to assess pro...

Open access Research Article 10.9734/cjast/2026/v45i94756

Design, Synthesis and Molecular Docking Study Evaluation of Acetylcholinesterase and Butyrylcholinesterase Inhibition Potential of 8-bromo-4-(2-(phenylethylidene)hydrazinyl)tetrazolo[1,5-a]quinoxaline Derivatives

F. O. Taiwo, I. J. Olawuni, O. B. Omoyeni, E. G. Fakola & C. A. Obafemi · Annual Research & Review in Biology · 2026

Aims: The aim of this study was to synthesize 8-bromo-4-(2-(1-phenylethylidene)hydrazinyl)tetrazolo[1,5-a]quinoxaline derivatives and assess their acetylcholinesterase and butyrylcholinesterase inhibitory potential. Methods: The 8-bromo-4-(2-(1-phenylethylidene) hydrazinyl)tetraz...

Open access Research Article 10.9734/arrb/2026/v41i92446