Brice Dali

Computer-Assisted Design of Hydroxamic Acid Derivatives Inhibitors of M1 Metallo Aminopeptidase of Plasmodium falciparum with Favorable Pharmacokinetic Profile

Niaré Adama, Hermann N’Guessan, Brice Dali & Eugene Megnassan · Journal of Pharmaceutical Research International · 2022

We virtually design here new subnanomolar range antimalarial, inhibitors of plasmodium falciparum M1 Aminopeptidase (PfA-M1), by means of structure-based molecular design. We developed the complexation QSAR models from Hydroxamic Acid derivatives (AHO). A linear correlation was e...

Open access Research Article 10.9734/jpri/2022/v34i607271

Virtual Design of Novel Coumarinyl-Substituted Sulfonamide Inhibitors of Carbonic Anhydrase II as Potential Drugs against Glaucoma

Eric Ziki, Ludovic Akonan, Koffi Charles Kouman, Brice Dali, Eugene Megnassan, Rita Kakou-Yao, Abodou Jules Tenon, Vladimir Frecer & Stanislav Miertus · Journal of Pharmaceutical Research International · 2023

Background: We have carried out virtual design of coumarinyl-substituted sulfonamides (CSAM) analogs as inhibitors of human carbonic anhydrase II (hCA II) endowed with favorable predicted pharmacokinetic profiles and potential therapeutic effects against glaucoma. Methods: modify...

Open access Research Article 10.9734/jpri/2023/v35i247424