Background: Ophthalmopathy, or thyroid eye disease (TED), is more often associated with Graves’ hyperthyroidism than Hashimoto’s thyroiditis. In the latter disorder, the pathogenesis of the eye signs may be different and the influence of well-known risk factors for the developmen...
Aims: Apart from its key role in bone metabolism vitamin D plays a role in immune function, cancer prevention and autoimmunity induction. Vitamin D insufficiency (25-50 nmol/L) and deficiency (serum level < 25 nmol/L) are very common in the West Sydney and Blue Mountains areas...
The pathogenesis of Graves’ ophthalmopathy is poorly understood, but there is evidence for the involvement of calsequestrin (CASQ1) as an autoantigen. Aim: To compare the frequency of the single nucleotide polymorphism (SNP) rs3838216 (located in intron 1 of CASQ1) in patients wi...