Balaji Srinivasan

Synthesis and Characterization of 4-Thiobutyl-triphenylphosphonium-pantetheine, a Pantetheine Derivative

Roald A. Lambrechts, Balaji Srinivasan, Edzard M. Geertsema, Gerrit J. Poelarends, Ody C. M. Sibon & Marianne De Villiers · Chemical Science International Journal · 2014

Pantetheine, a low molecular weight thiol, has been found to ameliorate symptoms in various disease models but specifically in Pantothenate Kinase-Associated Neurodegeneration (PKAN). Pantetheine is usually administered in its disulfide form (i.e. pantethine) since pantethine is...