A convenient Synthesis of 3-aryl-5-Hydroxyalkyl-1,2,4-oxadiazoles from a-hydroxy Esters and Amidoximes under Solvent-free Conditions
João Rufino de Freitas Filho, Jucleiton José Rufino de Freitas, Juliano Carlo Rufino Freitas, Aldicéia Luiz de Moura, Mauricélia Maria de Sousa Mata, André Ricardo França da Silva, Maria Verônica de Sales Barbosa & Jaqueline Ferreira Ramos · International Research Journal of Pure and Applied Chemistry · 2021
The present study aimed to synthesis and characterization of 3-aryl-5-hydroxyalkyl-1,2,4-oxadiazoles (5a-d, 6a-d, 7a/d, 8a-d and 9a-c). The 3-aryl-5-hydroxyalkyl-1,2,4-oxadiazoles were synthesized by treatment of arylamidoxime 1a-d with a-hydroxy esters for 4 hours without any so...
Open access
Research Article
10.9734/irjpac/2021/v22i1130446