Adeyemi Mary Adewumi

In-silico Evaluation of Allium sativum Derived Phytochemicals Reveals Promising Drug Candidates for p53-MDM2 Interaction in Osteosarcoma Therapy

Atanda Opeyemi Emmanuel, Adesikun Aanu Adedamola, Adeyeye Pius Oluwaseyi, Oyewale Malik Tomilola & Adeyemi Mary Adewumi · Journal of Applied Life Sciences International · 2025

Osteosarcoma is a rare but aggressive bone cancer with poor prognosis, largely due to chemoresistance and the absence of effective targeted therapies. The MDM2 oncoprotein, a negative regulator of the p53 tumour suppressor, has emerged as a key driver of osteosarcoma progression...