Adewale Adetutu, Olusoji Abiodun Owoade, Ifewumi Racheal Aderibigbe, Olubunmi Simeon Oyekunle, Peter Ifeoluwa Adegbola, Biodun Bukunmi Aborisade, Temitope Deborah OLANIYI & Fatima Aluko Abubakar·Journal of Pharmaceutical Research International·2020
Dimethylamine (DMA) and sodium nitrite (NaNO2) are present in numerous foods, food additive and environmental factors, which enhance chemical driven liver damage by inducing oxidative stress and cellular injury. Therefore, this study evaluated the possible therapeutic and protect...
Open access
Research Article10.9734/jpri/2020/v32i2530825
Aims: Hibiscus sabdariffa is a medicinal plant that is consumed for its health benefits in Africa. The study was designed to investigate the hepatoprotective potentials of Hibiscus polyphenolic rich extract (HPE), (a group of phenolic compounds occurring in the dried calyx of Hib...
Open access
Research Article10.9734/BJMMR/2013/3762
Background: Valproic acid (VPA) is an antiepileptic drug with a well-documented hepatotoxic effect among other several side effects. However, the effect of valproic acid administration on lipid profile and cardiovascular risk factors remains inconclusive and highly controversial....
Abiodun Olusoji Owoade, Adewale Adetutu, Olufemi Ogundeji Ogundipe, Akinade William Owoade & Esther Oluwakemi Kehinde·Asian Journal of Research in Biochemistry·2022
This study is aimed at investigating the effects of tamoxifen on lipid profile. In order to achieve this, tamoxifen was administered once daily intraperitoneally to the female rats at a dose of 2.07mg/kg body weight for 1 and 2 weeks, while a group of rats was allowed to recover...
Open access
Research Article10.9734/ajrb/2022/v10i330224
This study was carried out to compare the in-vitro antioxidant potentials, antidiabetic and phytochemical constituents of methanolic leaf extracts of Anthocleista djalonensis, Chrysophyllum albidium, Bauhinia thonningii, Daniellia oliveri, and Cola nitida. The results of this stu...
Open access
Research Article10.9734/jocamr/2021/v16i430302
Abiodun Olusoji Owoade, Adewale Adetutu, Olufemi Ogundeji Ogundipe & Akinade William Owoade·Asian Plant Research Journal·2021
The study was aimed to investigate the hypolipidemic potential of methanolic extract Rauvolfia vomitoria leaves in high cholesterol-fed rats. The preliminary study showed that R. vomitoria leaves were able to scavenge the 2,2-azino-bis (3-ethylbenzthiazoline-6-sufonic acid) (ABTS...
Open access
Research Article10.9734/aprj/2021/v8i430181
Various studies suggest that mortality due to liver disease in diabetic patients is very high; however, the recognition of DM as the primary cause of chronic liver disease is neglected in medical practice, we therefore evaluated the activities of Sarcocephalus latifolius leaf pow...
Open access
Research Article10.9734/jocamr/2021/v16i330292
Aims: The toxicity of ethanol whole plant extract of Euphorbia lateriflora was assessed in Albino Wistar rats. Methodology: The LD50 was at single dose of 5000 mg/kg body weight, the sub-acute dosage of the extract was administered orally at 250 and 500 mg/kg b.w.t twice daily fo...
Open access
Research Article10.9734/ejmp/2019/v29i130147
This study evaluated the antioxidant and possible protective effects of Celosia argentea against tissue injury caused by rifampicin administration. The antioxidant property of the aqueous extract of C. argentea was assessed in-vitro using 2,2-Diphenyl-1- picrylhydrazyl (DPPH), an...
Open access
Research Article10.9734/jalsi/2018/v19i430068
This study was designed to examine the hypoglycemic and antioxidant defense by methanolic extract of Zingiber officinale on alloxan induced diabetes in Wistar rats.The preliminary study showed that Z. officinale extract was able to scavenge the 2,2-Diphenyl-1-picrylhydrazyl (DPPH...
Open access
Research Article10.9734/JPRI/2017/34396
Aims: Hibiscus sabdariffa is a medicinal plant species that is consumed for its health benefits in Africa, therefore this study investigated the antioxidant properties of Hibiscus polyphenolic rich extract (HPE), prepared from Hibiscus sabdariffa. Place and Duration of Study: Sch...
Open access
Research Article10.9734/BJMMR/2016/26742
Aim: This study aimed to investigate the protective effects of Zingiber officinale Roscoe (ginger) and Curcuma longa Linn(turmeric) on tramadol-induced neurotoxicity. Study Design: Twenty male Wistar rats, with an average weight of 130 g, were randomly divided into four groups (n...
Abiodun Olusoji Owoade, Abdullahi Alausa, Adewale Adetutu, Akinade William Owoade, Olufemi Alamu Alamu & Olatundun Oludairo·Asian Journal of Research in Biochemistry·2021
This study evaluated the in- vitro antioxidant, phytochemical constituents and hepato-renal protective efficacy of Senna siamea methanolic extract in arsenic-induced oxidative stress. The results of this study show that S. siamea has strong antioxidant potentials against 2,2-Diph...
Open access
Research Article10.9734/ajrb/2021/v9i130194
Objectives: This study aimed to investigate the effects of codeine administration on some haematological and biochemical indices in rats. Materials and Methods: Therapeutic dose (5 mg/kg/day), high dose (25 mg/kg/day) and extreme dose (50 mg/kg/day) of codeine were administered o...
Open access
Research Article10.9734/ajrimps/2019/v6i330102
Aims: The study was aimed to investigate the efficacy of Telfairia occidentalis (T. occidentalis) extracts in the attenuation of CCl4-mediated oxidative stress. Place and Duration of Study: Department of Biochemistry, Ladoke Akintola University of Technology, Ogbomosho, Nigeria,...
Open access
Research Article10.9734/JAMPS/2016/29199
Michael Femi OMOTOSO, Temitope Deborah OLANIYI, Abiodun Bukunmi Aborisade & Adewale Adetutu·Asian Plant Research Journal·2024
Background: Life-threatening typhoidal salmonella infection is becoming more difficult to treat due to rising resistance to commonly used antibiotics. This resistance is aided by the biofilm-forming ability of the bacteria. This study investigated the in vitro and in vivo antisal...
Open access
Research Article10.9734/aprj/2024/v12i6277
Medicinal plants are natural resources, yielding valuable herbal products, which could be used in the treatment of various ailments. Natural products, such as plant extract, either as pure compounds or as standardized extracts provide unlimited opportunities for new drug discover...