Abodou Jules Tenon

QSAR Modelling of Novel Coumarin Derivatives for MAO-B Inhibition

Konan René Kambo, Koffi Charles Kouman, Ludovic Akonan, Akoun Abou, Eugene Megnassan, Rita Kakou-Yao & Abodou Jules Tenon · Journal of Pharmaceutical Research International · 2024

We report here the design of new inhibitors against human monoamine oxidase (hMAO-B) as potential treatment of Parkinson’s disease. We have completed computer-aided molecular design of MAO-B inhibitors by In situ modification of the reference crystal structure of 7-(3-chlorobenzy...

Open access Research Article 10.9734/jpri/2024/v36i107592

Virtual Design of Novel Coumarinyl-Substituted Sulfonamide Inhibitors of Carbonic Anhydrase II as Potential Drugs against Glaucoma

Eric Ziki, Ludovic Akonan, Koffi Charles Kouman, Brice Dali, Eugene Megnassan, Rita Kakou-Yao, Abodou Jules Tenon, Vladimir Frecer & Stanislav Miertus · Journal of Pharmaceutical Research International · 2023

Background: We have carried out virtual design of coumarinyl-substituted sulfonamides (CSAM) analogs as inhibitors of human carbonic anhydrase II (hCA II) endowed with favorable predicted pharmacokinetic profiles and potential therapeutic effects against glaucoma. Methods: modify...

Open access Research Article 10.9734/jpri/2023/v35i247424