Background: Valproic acid (VPA) is an antiepileptic drug with a well-documented hepatotoxic effect among other several side effects. However, the effect of valproic acid administration on lipid profile and cardiovascular risk factors remains inconclusive and highly controversial....
Abiodun Olusoji Owoade, Adewale Adetutu, Olufemi Ogundeji Ogundipe, Akinade William Owoade & Esther Oluwakemi Kehinde·Asian Journal of Research in Biochemistry·2022
This study is aimed at investigating the effects of tamoxifen on lipid profile. In order to achieve this, tamoxifen was administered once daily intraperitoneally to the female rats at a dose of 2.07mg/kg body weight for 1 and 2 weeks, while a group of rats was allowed to recover...
Open access
Research Article10.9734/ajrb/2022/v10i330224
This study was carried out to compare the in-vitro antioxidant potentials, antidiabetic and phytochemical constituents of methanolic leaf extracts of Anthocleista djalonensis, Chrysophyllum albidium, Bauhinia thonningii, Daniellia oliveri, and Cola nitida. The results of this stu...
Open access
Research Article10.9734/jocamr/2021/v16i430302
Abiodun Olusoji Owoade, Adewale Adetutu, Olufemi Ogundeji Ogundipe & Akinade William Owoade·Asian Plant Research Journal·2021
The study was aimed to investigate the hypolipidemic potential of methanolic extract Rauvolfia vomitoria leaves in high cholesterol-fed rats. The preliminary study showed that R. vomitoria leaves were able to scavenge the 2,2-azino-bis (3-ethylbenzthiazoline-6-sufonic acid) (ABTS...
Open access
Research Article10.9734/aprj/2021/v8i430181
Abiodun Olusoji Owoade, Abdullahi Alausa, Adewale Adetutu, Akinade William Owoade, Olufemi Alamu Alamu & Olatundun Oludairo·Asian Journal of Research in Biochemistry·2021
This study evaluated the in- vitro antioxidant, phytochemical constituents and hepato-renal protective efficacy of Senna siamea methanolic extract in arsenic-induced oxidative stress. The results of this study show that S. siamea has strong antioxidant potentials against 2,2-Diph...
Open access
Research Article10.9734/ajrb/2021/v9i130194
Objectives: This study aimed to investigate the effects of codeine administration on some haematological and biochemical indices in rats. Materials and Methods: Therapeutic dose (5 mg/kg/day), high dose (25 mg/kg/day) and extreme dose (50 mg/kg/day) of codeine were administered o...
Open access
Research Article10.9734/ajrimps/2019/v6i330102
This study evaluated the antioxidant and possible protective effects of Celosia argentea against tissue injury caused by rifampicin administration. The antioxidant property of the aqueous extract of C. argentea was assessed in-vitro using 2,2-Diphenyl-1- picrylhydrazyl (DPPH), an...
Open access
Research Article10.9734/jalsi/2018/v19i430068
This study was designed to examine the hypoglycemic and antioxidant defense by methanolic extract of Zingiber officinale on alloxan induced diabetes in Wistar rats.The preliminary study showed that Z. officinale extract was able to scavenge the 2,2-Diphenyl-1-picrylhydrazyl (DPPH...
Open access
Research Article10.9734/JPRI/2017/34396
Aims: The study was aimed to investigate the efficacy of Telfairia occidentalis (T. occidentalis) extracts in the attenuation of CCl4-mediated oxidative stress. Place and Duration of Study: Department of Biochemistry, Ladoke Akintola University of Technology, Ogbomosho, Nigeria,...
Open access
Research Article10.9734/JAMPS/2016/29199
Aims: Hibiscus sabdariffa is a medicinal plant species that is consumed for its health benefits in Africa, therefore this study investigated the antioxidant properties of Hibiscus polyphenolic rich extract (HPE), prepared from Hibiscus sabdariffa. Place and Duration of Study: Sch...
Open access
Research Article10.9734/BJMMR/2016/26742
Objectives: This study aimed to assess the haematological and nephrotoxic effects of diazepam at varying doses in male albino rats. Materials and Methods: Rats were administered therapeutic (0.062 mg/kg/day), high (0.33 mg/kg/day), and extremely high (0.661 mg/kg/day) doses of di...
Open access
Research Article10.9734/ajrb/2024/v14i6327
Aims: The toxicity of ethanol whole plant extract of Euphorbia lateriflora was assessed in Albino Wistar rats. Methodology: The LD50 was at single dose of 5000 mg/kg body weight, the sub-acute dosage of the extract was administered orally at 250 and 500 mg/kg b.w.t twice daily fo...
Open access
Research Article10.9734/ejmp/2019/v29i130147