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Abhimanyu Kumar Jha

Publications (4)

Demethylation of RARβ2 Gene Promoter by Withania somnifera in HeLa Cell Line

Abhimanyu Kumar Jha, Mohsen Nikbakht, Neena Capalash & Jagdeep Kaur · European Journal of Medicinal Plants · 2014

An important molecular target for cancer therapy is the possible reactivation of tumor suppressor genes that have been silenced by promoter methylation.  It was observed that the treatment of an adenocarcinoma cervical cancer cell line, HeLa with 20 µg/ml of the ethanolic extract...

Open access Research Article 10.9734/EJMP/2014/5975

Hypermethylation of Apoptotic Genes in Oral Squamous Cell Carcinoma

Aabhas Agarwal, Shivani Tyagi, Madhav Kumar & Abhimanyu Kumar Jha · Asian Journal of Biotechnology and Genetic Engineering · 2024

Oral squamous cell carcinoma (OSCC) presents a substantial worldwide health challenge due to its aggressive behavior and resistance to standard treatments, resulting in high mortality rates. Epigenetic changes, notably DNA hypermethylation, are pivotal in OSCC development as they...

Open access Research Article

Apoptotic Activity by Chemo-preventive Natural Compounds against Oral Squamous Cell Carcinoma

Nisha Rani, Neeraj Vaishnav, Runjhun Mathur & Abhimanyu Kumar Jha · Asian Oncology Research Journal · 2020

The general frequency and mortality consisting of Oral Squamous Cell Carcinoma (OSCC) is very high and the overall number of oral cancers has been consistently increasing in the world. Oral Squamous Cell Carcinoma (OSCC) is the most typical variety of oral cancer; it causes damag...

Open access Research Article

Reversal of Hypermethylation in Tumor Suppressor Genes Using Phytochemicals in Cervical Cancer

Saloni ., Archita Sharma, Runjhun Mathur & Abhimanyu Kumar Jha · European Journal of Medicinal Plants · 2019

Cervical cancer is most familiar neoplasm among women worldwide. Surgery, radiotherapy, and chemotherapy are common treatments, however high stage tumors have frequently poor prognosis. HPV 16 and 18 are major etiological factors for cervical cancer. Likewise, epigenetics is the...

Open access Research Article 10.9734/ejmp/2019/v28i230128