Background: Despite all efforts to establish the pathogenesis of malaria, it is far from being understood, and resistance to existing drugs remain a problem in several strains of Plasmodium. Different complications arise during malaria infection, and among these is the alteration...
Open access
Research Article10.9734/JALSI/2018/40708
Aim: In the present study, the alkaloid, flavonoid and saponin-rich extracts of the leaves and seeds of Moringa oleifera were partially-purified and the ACE inhibitory activities and patterns of inhibition determined. Methodology: Alkaloids, flavonoids and saponins were extracted...
Open access
Research Article10.9734/JABB/2016/21974
Aim: There are conflicting reports on the effect of peptides of the Renin Angiotensin System (RAS) on the pathogenesis of malaria infection. Captopril is a common antihypertensive drug that inhibits angiotensin-converting enzyme (ACE), a critical peptide of RAS, and its effect on...
Background: Alteration of redox status is a fundamental process in the manifestation of many diseases including malaria. Studies have demonstrated that peptides of the renin-angiotensin-aldosterone system (RAAS), such as Angiotensin Converting Enzyme and Angiotensin II, play a si...
Open access
Research Article10.9734/AJB2T/2018/41424
Aim: This study was carried out to investigate the effect of captopril on serum liver enzymes (AST, ALT, and ALP), total serum protein and kidney function parameters such as electrolytes (HCO3-, Cl-, Na+, and K+), urea and creatinine in Plasmodium berghei-infected mice. Methodol...
Open access
Research Article10.9734/JAMPS/2018/40599
Aim: This study was carried out to determine the serum lipid profile and electrolyte level and their association with severity of malaria among patients attending Muhammadu Abdullahi Wase Specialist Hospital, Kano State, Nigeria. Methodology: Blood samples were obtained from four...
Open access
Research Article10.9734/JOCAMR/2018/41215