Segregated Delivery of Rifampicin and Isoniazid from Fixed Dose Combination Bilayer Tablets for the Treatment of Tuberculosis
A. M. Silva, B. Abrahim-Vieira, F. A. do Carmo, L. H. do Amaral, L. C. Silva, C. S. Escudini, M. A. Lopes, V. P. Sousa, H. C. Castro, F. Veiga, C. R. Rodrigues, A. J. Ribeiro & L. M. Cabral · Journal of Pharmaceutical Research International · 2014
Aims: Develop an anti-tuberculosis (TB) Fixed Dose Combination (FDC) tablet containing an immediate release layer (IRL) composed of both rifampicin (RIF) and pyrazinamide (PYR) and a retarded release layer (RRL) comprised of isoniazid (INH) which would allow segregated delivery o...
Open access
Research Article
10.9734/BJPR/2014/11525